Faculty Research Groups

Elizabeth Boon, Assistant Professor

A.B. in Chemistry, Kenyon College, 1997
Ph.D. in Chemistry, California Institute of Technology, 2003
NIH Postdoctoral Fellowship, University of California, Berkeley, 2003-2006

Phone: (631) 632-7945

Email:

Positions Available
The Boon Group Website

Biochemistry, Bioinorganic Chemistry, and Chemical Biology

Fundamentals and applications in biological sensing and signaling

We seek to understand sensing and signal transduction in bacteria from a molecular to a community level. As we learn more about the fundamentals of nitric oxide signaling in bacteria, known sensor proteins will be used in a modular approach for the design and engineering of new proteins and peptides that either mimic known structure or function or create new structure or function, with the aim of fundamentally understanding the natural system and using this knowledge to develop practical applications, primarily in human health and biotechnology.

The Boon Group is affiliated with several different graduate programs

Chemical Biology Training Program, the Graduate Program in Biochemistry & Structural Biology, the Graduate Program in Molecular Genetics & Microbiology, and the Graduate Program in Molecular & Cellular Biology.

For more information, visit our group website!

Awards/Honors

PECASE, 2009
ACS PROGRESS/Dreyfus Lectureship Award, 2008
NYSTAR James D. Watson Young Investigator Award, 2008
Office of Naval Research Young Investigator Award, 2008
Rising Star Award from the Research Foundation of SUNY, 2008

Publications

Boon Group Publications

Dai, Z.; Boon, E.M.*(2010) XANES study on the local electronic and geometric properties of the heme iron center in an O₂-binding H-NOX domain. Submitted to Journal of Inorganic Biochemistry.

Dai, Z.; Boon, E.M.* (2010) Sensitive and selective detection of cyanide using an H-NOX domain. Journal of the American Chemical Society, DOI: 10.1021/ja101674z.

Liu, N.; Pak, T.; Boon, E.M.* (2010) Characterization of a diguanylate cyclase from Shewanella woodyi with cyclase and phosphodiesterase activities. Molecular BioSystems, DOI: 10.1039/c002246b

Boon, E.M.* (2009) Review of Biochemistry of Signal Transduction and Regulation, Fourth Enlarged and Improved Edition, by Gerhard Krauss for The Quarterly Review of Biology, 84 (2), 200.

Postdoctoral Publications

Weinert, E. E.; Tran, R.; Boon, E.M.; Mathies, R.A.; Marletta, M.A. (2010) Role of Ile5 in the conformational flexibility of an O₂-binding H-NOX domain. Submitted to Biochemistry.

Tran, R.; Boon, E.M.; Marletta, M.A.; Mathies, R.A. (2009) Resonance Raman spectra of an O₂-binding H-NOX domain reveals heme relaxation upon mutation. Biochemistry, 48, 8568-8577.

Olea, C.; Boon, E.M.; Pellicena, P.; Kuriyan, J.; Marletta, M.A. (2008) Probing the function of heme distortion in the H-NOX family. American Chemical Society Chemical Biology, 3, 703-710.

Boon, E.M.; Marletta, M.A. (2006) Sensitive and selective detection of nitric oxide using an H-NOX domain. Journal of the American Chemical Society, 128, 10022-10023.

Boon, E.M.; Davis, J.H.; Karow, D.S.; Huang, S.H.; Tran, R.; Miazgowicz, M.M.; Mathies, R.; Marletta, M.A. (2006) Characterization of NO binding to prokaryotic homologs of the sGC 1 H-NOX domain. Journal of Biological Chemistry, 281, 21892-21902.

Boon, E.M.; Marletta, M.A. (2005) Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins. Current Opinion in Chemical Biology, 9, 441-446.

Boon, E.M.; Huang, S.H.; Marletta, M.A. (2005) A molecular basis for NO selectivity in soluble guanylate cyclase. Nature Chemical Biology, 1, 53-59.

Boon, E.M.; Marletta, M.A. (2005) Ligand specificity of H-NOX domains: From sGC to bacterial NO sensors. Journal of Inorganic Biochemistry, 99, 892-902.

Pellicena, P.; Karow, D.S.; Boon, E.M.; Marletta, M.A.; Kuriyan, J. (2004) Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proceedings of the National Academy of Science USA, 101, 12854-12859.

Graduate Publications

Yavin, Eylon; Boal, Amie K.; Stemp, E.D.A.; Boon, E.M.; O’Shea, V.L.; David, S.S.; Barton, J.K. (2005) Protein-DNA charge transport: Redox activation of a DNA repair protein by guanine radical. Proceedings of the National Academy of Science USA, 102, 3546-3551.

Boon, E.M.; Barton, J.K. (2003) DNA electrochemistry as a probe of base pair stacking in A-, B-, and Z-form DNA. Bioconjugate Chemistry, 14, 1140-1147.

Boon, E.M.; Barton, J.K.; Bhaghat, V.; Nersissian, M.; Wang, W.; Hill, M.G. (2003) Reduction of ferricyanide by methylene blue at a DNA-modified rotating-disk electrode. Langmuir, 19, 9255-9259.

Boon, E.M.; Livingston, A.L.; Chmiel, N.H.; David, S.S.; Barton, J.K. (2003) DNA-mediated charge transport for DNA repair. Proceedings of the National Academy of Science USA, 100, 12543-12547.

Boon, E.M.; Jackson, N.M.; Wightman, M.D.; Kelley, S.O.; Hill, M.G.; Barton, J.K. (2003) Intercalative stacking: A critical feature of DNA charge transport electrochemistry. Journal of Physical Chemistry B, 107, 11805-11812.

Boon, E.M.; Kisko, J.L.; Barton, J.K. (2002) Detection of base mismatches using intercalators. Methods in Enzymology, 353, 506-522.

Boon, E.M.; Barton, J.K. (2002) Charge transport in DNA. Current Opinion in Structural Biology, 12, 320-329.

Boon, E.M.; Barton, J.K.; Pradeepkumar, P.I.; Isaksson, J.; Petit, C.; Chattopadhyaya, J. (2002) An electrochemical probe of DNA stacking in an antisense oligonucleotide containing a C3’-endo locked sugar. Angewandte Chemie International Edition, 114, 3552-3555.

Boon, E.M.; Pope, M.A.; Williams, S.D.; David, S.S.; Barton, J.K. (2002) DNA-mediated charge transport as a probe of MutY/DNA interaction. Biochemistry, 41, 8464-8470.

Boon, E.M.; Salas, J.E.; Barton, J.K. (2002) An electrical probe of DNA-protein interactions on DNA-modified surfaces. Nature Biotechnology, 20, 282-286.

Sam, M.†; Boon, E.M.†; Barton, J.K.; Hill M.G.; Spain, M.S. (2001) Morphology of 15-mer duplexes tethered to Au(111) through 3' and 5' linkages via scanning probe microscopy. Langmuir, 17, 5727-5730.
†equal authorship

Boon, E.M.; Ceres, D.M.; Drummond, T.G.; Hill, M.G.; Barton, J.K. (2000) Mutation detection by electrocatalysis at DNA-modified electrodes. Nature Biotechnology, 18, 1096-1100.

Kelley, S.O.; Boon, E.M.; Barton, J.K.; Jackson, N.M.; Hill, M.G. (1999) Single base mismatch detection based on charge transduction through DNA. Nucleic Acids Research, 27, 4830-4837.

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