Faculty Research Groups

Jonathan (Jon) G. Rudick, Assistant Professor

B.S. Case Western Reserve University, 2000.
Ph.D. University of Pennsylvania, 2005
Scientist, Procter & Gamble 2005-2007
NIH Postdoctoral Fellowship, University of Pennsylvania, School of Medicine 2007-2010

 

Phone: (631) 632-6632

Email:

The Rudick Group Website

 

 

Research Interests

Our research aims to create nanostructures whose functions arise through precise three-dimensional structure. Our approach relies on both chemical synthesis and self-assembly. Rigorous characterization of both structure and function are used to inform future design of macromolecules and supramolecular assemblies to meet challenges in nanoscience, biotechnology, and chemical biology.

Biohybrid Macromolecules

Folding in proteins creates atomically precise three-dimensional structures that have been difficult to cultivate into functional assemblies of nanostructures. Appropriate design of synthetic macromolecule-protein conjugates is anticipated to facilitate organization of proteins into nanostructured arrays that retain the native protein's structure and function.

Macromolecular Chirality and Folding

Synthetic molecules capable of adopting well-defined conformations (foldamers) offer an alternative to proteins in nanoscience and chemical biology. De novo design of minimalist proteins (a-peptide foldamers) highlights the potential to elucidate the principles that underlie macromolecular folding. An oligomer approach to macromolecular chirality and folding can bridge the knowledge gap between proteins and polymers.

Conjugated Polymers

Conjugated polymers are attractive targets for nanoscience, as molecular wires, and alternative energy research, as photovoltaic components. Individualized conjugated polymers are the ideal targets for such applications. Self-organized arrays of molecular wires are being targeted through architectural modification of conjugated polymers.

Publications

16. Jonathan G. Rudick & Virgil Percec. "Nanomechanical function made possible by suppressing structural transformations of polyarylacetylenes." Macromolecular Chemistry and Physics 2008, 209(17), 1759–1768. (DOI: 10.1002/macp.200800271) Special Article Series devoted to Acetylene-Derived Functional Polymers. Highlighted by the American Chemical Society as "Noteworthy Chemistry."
15. Jonathan G. Rudick & Virgil Percec. "Induced helical backbone conformations of self-organizable dendronized polymers." Accounts of Chemical Research 2008, 41(12), 1641–1652. (DOI: 10.1021/ar800086w) Special issue devoted to Nanoscience.
14. Virgil Percec, Jonathan G. Rudick, Mihai Peterca & Paul A. Heiney. "Nanomechanical function from self–organizable dendronized helical polyphenylacetylenes." Journal of the American Chemical Society 2008, 130(23), 7503–7508. (DOI: 10.1021/ja801863e) Highlighted in Nature Nanotechnology News & Views and on the Nature Chemistry website.
13. Virgil Percec, Jonathan G. Rudick, Mihai Peterca, Michael E. Yurchenko, Jan Smidrkal & Paul A. Heiney. "Supramolecular structural diversity among first-generation hybrid dendrimers and twin dendrons." Chemistry – A European Journal 2008, 14(11), 3355–3362. (DOI: 10.1002/chem.200701658)
12. Virgil Percec, Mihai Peterca, Michael E. Yurchenko, Jonathan G. Rudick & Paul A. Heiney. "Thixotropic twin-dendritic organogelators." Chemistry – A European Journal 2008, 14(3), 909–918. (DOI: 10.1002/chem.200701273)
11. Virgil Percec, Mihai Peterca, Jonathan G. Rudick, Emad Aqad, Mohammad R. Imam & Paul A. Heiney. "Self–assembling phenylpropyl ether dendronized helical polyphenylacetylenes." Chemistry – A European Journal 2007, 13(34), 9572–9581. (DOI: 10.1002/chem.200701008)
10. Virgil Percec, Jonathan G. Rudick, Mihai Peterca, Emad Aqad, Mohammad R. Imam & Paul A. Heiney. "Synthesis, Structural and Retrostructural Analysis of Helical Dendronized Poly(1 naphthylacetylene)s." Journal of Polymer Science, Part A: Polymer Chemistry 2007, 45(21), 4974–4987. (DOI: 10.1002/pola.22265)
9. Jonathan G. Rudick & Virgil Percec. "Helical chirality in dendronized polyarylacetylenes." New Journal of Chemistry 2007, 37(7), 1083–1096. (DOI: 10.1039/b616449h)
8. Virgil Percec, Emad Aqad, Mihai Peterca, Jonathan G. Rudick, Lance Lemon, Juan C. Ronda, Binod B. De, Paul A. Heiney & E. W. Meijer. "Steric communication of chiral information observed in amphiphilic dendronized polyacetylenes." Journal of the American Chemical Society 2006, 128(50), 16365–16372. (DOI: 10.1021/ja0665848)
7. Virgil Percec, Jonathan G. Rudick, Martin Wagner, Makoto Obata, Catherine M. Mitchell, Wook–Dong Cho & Sergei N. Magonov. "AFM visualization of individual and periodic assemblies of a helical dendronized polyphenylacetylene on graphite." Macromolecules 2006, 39(21), 7342–7351. (DOI: 10.1021/ma060845g)
6. Virgil Percec, Jonathan G. Rudick, Mihai Peterca, Sasha R. Staley, Martin Wagner, Makoto Obata, Catherine M. Mitchell, Wook–Dong Cho, Venkatachalapthy S. K. Balagurusamy, James N. Lowe, Martin Glodde, Oliver Weichold, Kyung J. Chung, Nicholas Ghionni, Sergei N. Magonov & Paul A. Heiney. "Synthesis, structural analysis, and visualization of a library of dendronized polyphenylacetylenes." Chemistry – A European Journal 2006, 12(22), 5731–5746. (DOI: 10.1002/chem.200600009)
5. Virgil Percec, Jonathan G. Rudick, Mihai Peterca, Martin Wagner, Makoto Obata, Catherine M. Mitchell, Wook–Dong Cho, Venkatachalapthy S. K. Balagurusamy & Paul A. Heiney. "Thermoreversible cis–cisoidal to cis–transoidal isomerization of helical dendronized polyphenylacetylenes." Journal of the American Chemical Society 2005, 127(43), 15257–15264. (DOI: 10.1021/ja055406w)
4. Virgil Percec, Jonathan G. Rudick & Emad Aqad. "Diminished helical character in para–substituted cis–transoidal polyphenylacetylenes due to intramolecular electrocyclization." Macromolecules 2005, 38(17), 7205-7206. (DOI: 10.1021/ma051536d)
3. Virgil Percec & Jonathan G. Rudick. "Independent electrocyclization and oxidative chain cleavage along the backbone of cis–poly(phenylacetylene)." Macromolecules 2005, 38(17), 7241–7250. (DOI: 10.1021/ma051060y)
2. Virgil Percec, Makoto Obata, Jonathan G. Rudick, Binod B. De, Martin Glodde, Tushar K. Bera, Sergei N. Magonov, Venkatachalapthy S. K. Balagurusamy & Paul A. Heiney. "Synthesis, structural analysis, and visualization of poly(2–ethynyl–9–substituted carbazole)s and poly(3–ethynyl–9–substituted carbazole)s containing chiral and achiral minidendritic substituents." Journal of Polymer Science, Part A: Polymer Chemistry 2002, 40(20), 3509–3533. (DOI: 10.1002/pola.10458)
1. Virgil Percec, Jonathan G. Rudick, Paul Nombel & Wlodzimierz Buchowicz. "Dramatic decrease of the cis-content and molecular weight of cis-transoidal polyphenylacetylene at 23 °C in solutions prepared in air." Journal of Polymer Science, Part A: Polymer Chemistry 2002, 40(19), 3212–3220. (DOI: 10.1002/pola.10421)

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